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Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids

Morphine and other μ opioids regulate a number of intracellular signaling pathways, including the one mediated by phospholipase C (PLC). By studying PLC β3-deficient mice, we have established a strong link between PLC and μ opioid-mediated responses at both the behavioral and cellular levels. Mice l...

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Detalhes bibliográficos
Main Authors: Xie, Wei, Samoriski, Gary M., McLaughlin, Jay P., Romoser, Valerie A., Smrcka, Alan, Hinkle, Patricia M., Bidlack, Jean M., Gross, Robert A., Jiang, Huiping, Wu, Dianqing
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC17897/
https://ncbi.nlm.nih.gov/pubmed/10468617
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