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Investigation of ribosome binding by the Shiga toxin A1 subunit, using competition and site-directed mutagenesis.

The enzymatic subunit of Shiga toxin (StxA1) is a member of the ribosome-inactivating protein (RIP) family, which includes the ricin A chain as well as other examples of plant toxins. StxA1 catalytically depurinates a well-conserved GAGA tetra-loop of 28S rRNA which lies in the acceptor site of euka...

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Bibliografiske detaljer
Main Authors: Skinner, L M, Jackson, M P
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC178838/
https://ncbi.nlm.nih.gov/pubmed/9023224
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