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Distinct memory CD4(+) T-cell subsets mediate immune recognition of Epstein Barr virus nuclear antigen 1 in healthy virus carriers

CD4(+) T cells, specific for transforming latent infection with the Epstein Barr virus (EBV), consistently recognize the nuclear antigen 1 of EBV (EBNA1). EBNA1-specific effector CD4(+) T cells are primarily T-helper 1 (TH1) polarized. Here we show that most healthy EBV carriers have such IFN-secret...

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Detalhes bibliográficos
Main Authors: Heller, Kevin N., Upshaw, Jenica, Seyoum, Beza, Zebroski, Henry, Münz, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785143/
https://ncbi.nlm.nih.gov/pubmed/16985171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-023663
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