Reduced expression of inducible gelatinase B/matrix metalloproteinase-9 in monocytes from patients with myelodysplastic syndrome: correlation of inducible levels with the percentage of cytogenetically marked cells and with marrow cellularity

Regulatory molecules produced by stromal cells are often membrane bound until cleaved by matrix metalloproteinases (MMPs); cleavage can either activate or inactivate regulatory functions. We report here that marrow stromal cells induce the expression of MMP-9 in monocytes. Induction was contact inde...

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Autores principales: Iwata, Mineo, Pillai, Manoj, Ramakrishnan, Aravind, Hackman, Robert C., Deeg, H. Joachim, Opdenakker, Ghislain, Torok-Storb, Beverly
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2007
Materias:
Hematopoiesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785081/
https://ncbi.nlm.nih.gov/pubmed/16954500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-020289
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