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Reduced expression of inducible gelatinase B/matrix metalloproteinase-9 in monocytes from patients with myelodysplastic syndrome: correlation of inducible levels with the percentage of cytogenetically marked cells and with marrow cellularity

Regulatory molecules produced by stromal cells are often membrane bound until cleaved by matrix metalloproteinases (MMPs); cleavage can either activate or inactivate regulatory functions. We report here that marrow stromal cells induce the expression of MMP-9 in monocytes. Induction was contact inde...

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Detalhes bibliográficos
Main Authors: Iwata, Mineo, Pillai, Manoj, Ramakrishnan, Aravind, Hackman, Robert C., Deeg, H. Joachim, Opdenakker, Ghislain, Torok-Storb, Beverly
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785081/
https://ncbi.nlm.nih.gov/pubmed/16954500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-020289
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