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Protein synthesis by native chemical ligation: Expanded scope by using straightforward methodology

The total chemical synthesis of proteins has great potential for increasing our understanding of the molecular basis of protein function. The introduction of native chemical ligation techniques to join unprotected peptides next to a cysteine residue has greatly facilitated the synthesis of proteins...

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Autors principals: Hackeng, Tilman M., Griffin, John H., Dawson, Philip E.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC17843/
https://ncbi.nlm.nih.gov/pubmed/10468563
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