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Primitive hematopoietic cells resist HIV-1 infection via p21(Waf1/Cip1/Sdi1)
Hematopoietic stem cells are resistant to HIV-1 infection. Here, we report a novel mechanism by which the cyclin-dependent kinase inhibitor (CKI) p21(Waf1/Cip1/Sdi1) (p21), a known regulator of stem cell pool size, restricts HIV-1 infection of primitive hematopoietic cells. Modifying p21 expression...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Clinical Investigation
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1783820/ https://ncbi.nlm.nih.gov/pubmed/17273559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28971 |
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