Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon–carbon bond cleavage during α-oxidation of 3-methyl-branched fatty acids

In the third step of the α-oxidation of 3-methyl-branched fatty acids such as phytanic acid, a 2-hydroxy-3-methylacyl-CoA is cleaved into formyl-CoA and a 2-methyl-branched fatty aldehyde. The cleavage enzyme was purified from the matrix protein fraction of rat liver peroxisomes and identified as a...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Foulon, Veerle, Antonenkov, Vasily D., Croes, Kathleen, Waelkens, Etienne, Mannaerts, Guy P., Van Veldhoven, Paul P., Casteels, Minne
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1999
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17838/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10468558/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.18.10039
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