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Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon–carbon bond cleavage during α-oxidation of 3-methyl-branched fatty acids

In the third step of the α-oxidation of 3-methyl-branched fatty acids such as phytanic acid, a 2-hydroxy-3-methylacyl-CoA is cleaved into formyl-CoA and a 2-methyl-branched fatty aldehyde. The cleavage enzyme was purified from the matrix protein fraction of rat liver peroxisomes and identified as a...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Proc Natl Acad Sci U S A
المؤلفون الرئيسيون: Foulon, Veerle, Antonenkov, Vasily D., Croes, Kathleen, Waelkens, Etienne, Mannaerts, Guy P., Van Veldhoven, Paul P., Casteels, Minne
التنسيق: Artigo
اللغة:Inglês
منشور في: National Academy of Sciences 1999
الموضوعات:
الوصول للمادة أونلاين:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17838/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10468558/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.18.10039
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