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Adenosine inhibits activity of hypocretin/orexin neurons via A1 receptor in the lateral hypothalamus: a possible sleep-promoting effect

Neurons in the lateral hypothalamus (LH) that contain hypocretin/orexin have been established as important promoters of arousal. Deficiencies in the hypocretin/orexin system lead to narcolepsy. The inhibition of hypocretin/orexin neurons by sleep-promoting neurotransmitters has been suggested as one...

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Detalhes bibliográficos
Main Authors: Liu, Zhong-Wu, Gao, Xiao-Bing
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783688/
https://ncbi.nlm.nih.gov/pubmed/17093123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00873.2006
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