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Rac1-induced cell migration requires membrane recruitment of the nuclear oncogene SET

The Rho GTPase Rac1 controls cell adhesion and motility. The effector loop of Rac1 mediates interactions with downstream effectors, whereas its C-terminus binds the exchange factor β-Pix, which mediates Rac1 targeting and activation. Here, we report that Rac1, through its C-terminus, also binds the...

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Библиографические подробности
Главные авторы: ten Klooster, Jean Paul, Leeuwen, Ingrid v, Scheres, Nina, Anthony, Eloise C, Hordijk, Peter L
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2007
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783461/
https://ncbi.nlm.nih.gov/pubmed/17245428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601518
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