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Rac1-induced cell migration requires membrane recruitment of the nuclear oncogene SET

The Rho GTPase Rac1 controls cell adhesion and motility. The effector loop of Rac1 mediates interactions with downstream effectors, whereas its C-terminus binds the exchange factor β-Pix, which mediates Rac1 targeting and activation. Here, we report that Rac1, through its C-terminus, also binds the...

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Detalhes bibliográficos
Main Authors: ten Klooster, Jean Paul, Leeuwen, Ingrid v, Scheres, Nina, Anthony, Eloise C, Hordijk, Peter L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783461/
https://ncbi.nlm.nih.gov/pubmed/17245428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601518
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