Multiple cytokines sharing the common receptor γ chain can induce CD154/CD40 ligand expression by human CD4(+) T lymphocytes via a cyclosporin A-resistant pathway

Expression of CD154/CD40 ligand (CD154/CD40L), an important molecular component of CD4(+) T-cell help, can be triggered by T-cell receptor (TCR) stimulation. Dephosphorylation of the transcriptional element Nuclear Factor of Activated T cells-1 (NFAT1) is a critical activation step in the TCR-initia...

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Bibliographic Details
Main Author: Fayen, John D
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2001
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783314/
https://ncbi.nlm.nih.gov/pubmed/11722644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2001.01296.x
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