Interleukin-12 and interleukin-2-induced invariant natural killer T-cell cytokine secretion and perforin expression independent of T-cell receptor activation

Human invariant natural killer (iNK) T cells expressing an invariant Vα24-Jα15 T-cell receptor (TCR) are thought to be important regulators of autoimmunity and tumour surveillance. Two major subsets of iNK T cells, CD4(+) or CD4(−) CD8(−) are known to exist, but the in vivo importance of CD4 express...

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Detalhes bibliográficos
Main Authors: Hou, Runhua, Goloubeva, Olga, Neuberg, Donna S, Strominger, Jack L, Wilson, S Brian
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2003
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783023/
https://ncbi.nlm.nih.gov/pubmed/12941138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2003.01701.x
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