In vivo maintenance of T-lymphocyte unresponsiveness induced by thymic medullary epithelium requires antigen presentation by radioresistant cells

The T-cell repertoire developing in the thymus is rid of autospecific cells by the process of thymic negative selection. Recognition of major histocompatibility complex (MHC)/self-peptide complexes expressed by thymic antigen-presenting cells (APC) of bone marrow origin leads to induction of apoptot...

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Autores principales: Hudrisier, Denis, Feau, Sonia, Bonnet, Véronique, Romagnoli, Paola, Van Meerwijk, Joost P M
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2003
Materias:
Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782865/
https://ncbi.nlm.nih.gov/pubmed/12519299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2003.01546.x
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