Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division

Cells expressing indoleamine 2,3-dioxygenase (IDO), an enzyme which catabolizes tryptophan, prevent T-cell proliferation in vitro, suppress maternal antifetal immunity during pregnancy and inhibit T-cell-mediated responses to tumour-associated antigens. To examine the mechanistic basis of these phen...

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Detalhes bibliográficos
Main Authors: Lee, Geon Kook, Park, Hyeon Jin, Macleod, Megan, Chandler, Phillip, Munn, David H, Mellor, Andrew L
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782830/
https://ncbi.nlm.nih.gov/pubmed/12460190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2002.01526.x
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