Interleukin-3, but not granulocyte–macrophage colony-stimulating factor and interleukin-5, inhibits apoptosis of human basophils through phosphatidylinositol 3-kinase: requirement of NF-κB-dependent and -independent pathways

Basophils are key effector cells of allergic reactions. Although proinflammatory cytokines, such as interleukin (IL)-3, granulocyte–macrophage colony-stimulating factor (GM–CSF) and IL-5, inhibit eosinophil apoptosis in vitro, little is known about basophil apoptosis, and the signalling mechanisms r...

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Detalhes bibliográficos
Main Authors: Zheng, Xueyan, Karsan, Aly, Duronio, Vincent, Chu, Fanny, Walker, David C, Bai, Tony R, Schellenberg, R Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782810/
https://ncbi.nlm.nih.gov/pubmed/12423306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2002.01517.x
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