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CD20-mediated apoptosis: signalling through lipid rafts

CD20 is an effective target for therapeutic B-cell depletion with monoclonal antibodies. One proposed mechanism of action is direct cytotoxicity mediated via tyrosine kinase-dependent signalling pathways activated upon CD20 cross-linking. The association of CD20 with membrane microdomains known as l...

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Detalhes bibliográficos
Main Authors: Deans, Julie P, Li, Haidong, Polyak, Maria J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782791/
https://ncbi.nlm.nih.gov/pubmed/12383196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2002.01495.x
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