Insight into the potential for DNA idiotypic fusion vaccines designed for patients by analysing xenogeneic anti-idiotypic antibody responses

DNA vaccines induce immune responses against encoded proteins, and have clear potential for cancer vaccines. For B-cell tumours, idiotypic (Id) immunoglobulin encoded by the variable region genes provides a target antigen. When assembled as single chain Fv (scFv), and fused to an immunoenhancing seq...

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Bibliographic Details
Main Authors: Forconi, Francesco, King, Catherine A, Sahota, Surinder S, Kennaway, Christopher K, Russell, Nigel H, Stevenson, Freda K
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2002
Subjects:
Tumour Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782777/
https://ncbi.nlm.nih.gov/pubmed/12225361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2002.01452.x
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