Interleukin-4 supports interleukin-12-induced proliferation and interferon-γ secretion in human activated lymphoblasts and T helper type 1 cells

Interleukin-12 (IL-12) and IL-4 are known to differentially promote T helper (Th) cell differentiation. While IL-12 induces interferon-γ (IFN-γ) production and maturation of Th1 cells, IL-4 is thought to antagonize IL-12 and to favour Th2 development. Here we studied the combined action of various c...

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Main Authors: Kriegel, Martin A, Tretter, Theresa, Blank, Norbert, Schiller, Martin, Gabler, Christoph, Winkler, Silke, Kalden, Joachim R, Lorenz, Hanns-Martin
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2006
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782327/
https://ncbi.nlm.nih.gov/pubmed/16762027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2006.02404.x
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