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The role of X-chromosome inactivation in female predisposition to autoimmunity

INTRODUCTION: A reduction in the sex ratio (male : female) is characteristic of most autoimmune disorders. The increased prevalence in females ranges from a modest 2:1 for multiple sclerosis [1], to approximately 10:1 for systemic lupus erythematosus [2]. This tendency toward autoimmunity in females...

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Detalhes bibliográficos
Main Authors: Chitnis, Smita, Monteiro, Joanita, Glass, David, Apatoff, Brian, Salmon, Jane, Concannon, Patrick, Gregersen, Peter K
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC17816/
https://ncbi.nlm.nih.gov/pubmed/11056674
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