Sustained Phenotypic Correction in a Mouse Model of Hypoalphalipoproteinemia with a Helper-Dependent Adenovirus Vector

We examined the efficacy and host response to the adenovirus (Ad)-mediated delivery of human apolipoprotein A-I (APOA1) gene to the liver of APOA1(−/−) mice. Administration of a first generation vector (FGAd-AI) resulted in a transient appearance of APOA1 in plasma and induced an anti-APOA1 antibody...

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Main Authors: Oka, Kazuhiro, Belalcazar, L. Maria, Dieker, Carrie, Nour, Elie A., Nuno-Gonzalez, Patricia, Paul, Antoni, Cormier, Shelley, Shin, Jae-Kyung, Finegold, Milton, Chan, Lawrence
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1780075/
https://ncbi.nlm.nih.gov/pubmed/16957769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.gt.3302819
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