Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons

The extracellular signal-regulated kinases (ERK) signalling cascade is a key pathway that mediates the NMDA receptor (NMDAR)-dependent neuronal plasticity and survival. However, it is not clear yet how NMDARs regulate ERK activity. Stimulation of the NMDARs induces a complex modification of ERK that...

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Bibliographic Details
Main Authors: Ivanov, Anton, Pellegrino, Christophe, Rama, Sylvain, Dumalska, Iryna, Salyha, Yuriy, Ben-Ari, Yehezkel, Medina, Igor
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2006
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1779993/
https://ncbi.nlm.nih.gov/pubmed/16513670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.105510
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