Disease-Causing Mutations in Proteins: Structural Analysis of the CYP1b1 Mutations Causing Primary Congenital Glaucoma in Humans

In this communication, we report an in-depth structure-based analysis of the human CYP1b1 protein carrying disease-causing mutations that are discovered in patients suffering from primary congenital glaucoma (PCG). The “wild-type” and the PCG mutant structures of the human CYP1b1 protein obtained fr...

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Autori principali: Achary, Malkaram S., Reddy, Aramati B. M., Chakrabarti, Subhabrata, Panicker, Shirly G., Mandal, Anil K., Ahmed, Niyaz, Balasubramanian, Dorairajan, Hasnain, Seyed E., Nagarajaram, Hampapathalu A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Biophysical Society 2006
Soggetti:
Biophysical Theory and Modeling
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1779944/
https://ncbi.nlm.nih.gov/pubmed/16963504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.085498
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