The Architecture of the Adhesive Apparatus of Cultured Osteoclasts: From Podosome Formation to Sealing Zone Assembly

BACKGROUND: Osteoclasts are bone-degrading cells, which play a central role in physiological bone remodeling. Unbalanced osteoclast activity is largely responsible for pathological conditions such as osteoporosis. Osteoclasts develop specialized adhesion structures, the so-called podosomes, which su...

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Bibliographic Details
Main Authors: Luxenburg, Chen, Geblinger, Dafna, Klein, Eugenia, Anderson, Karen, Hanein, Dorit, Geiger, Benny, Addadi, Lia
Format: Artigo
Language:Inglês
Published: Public Library of Science 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1779809/
https://ncbi.nlm.nih.gov/pubmed/17264882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000179
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