The human adult subtype ACh receptor channel has high Ca(2+) permeability and predisposes to endplate Ca(2+) overloading

Slow-channel congenital myasthenic syndrome, caused by mutations in subunits of the endplate ACh receptor (AChR), results in prolonged synaptic currents and excitotoxic injury of the postsynaptic region by Ca(2+) overloading. The Ca(2+) overloading could be due entirely to the prolonged openings of...

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Detalhes bibliográficos
Main Authors: Fucile, Sergio, Sucapane, Antonietta, Grassi, Francesca, Eusebi, Fabrizio, Engel, Andrew G
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2006
Assuntos:
Cellular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1779694/
https://ncbi.nlm.nih.gov/pubmed/16527851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.108092
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