HS1 Functions as an Essential Actin-Regulatory Adaptor Protein at the Immune Synapse

HS1, the leukocyte-specific homolog of cortactin, regulates F-actin in vitro and is phosphorylated in response to TCR ligation, but its role in lymphocyte activation has not been addressed. We demonstrate that HS1-deficient T cells fail to accumulate F-actin at the immune synapse (IS) and, upon TCR...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gomez, Timothy S., McCarney, Sean D., Carrizosa, Esteban, Labno, Christine M., Comiskey, Erin O., Nolz, Jeffrey C., Zhu, Peimin, Freedman, Bruce D., Clark, Marcus R., Rawlings, David J., Billadeau, Daniel D., Burkhardt, Janis K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2006
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1779661/
https://ncbi.nlm.nih.gov/pubmed/16782030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2006.03.022
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg