HS1 Functions as an Essential Actin-Regulatory Adaptor Protein at the Immune Synapse

HS1, the leukocyte-specific homolog of cortactin, regulates F-actin in vitro and is phosphorylated in response to TCR ligation, but its role in lymphocyte activation has not been addressed. We demonstrate that HS1-deficient T cells fail to accumulate F-actin at the immune synapse (IS) and, upon TCR...

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Detalhes bibliográficos
Main Authors: Gomez, Timothy S., McCarney, Sean D., Carrizosa, Esteban, Labno, Christine M., Comiskey, Erin O., Nolz, Jeffrey C., Zhu, Peimin, Freedman, Bruce D., Clark, Marcus R., Rawlings, David J., Billadeau, Daniel D., Burkhardt, Janis K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1779661/
https://ncbi.nlm.nih.gov/pubmed/16782030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2006.03.022
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