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The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like β-grasp domains

BACKGROUND: Ubiquitin (Ub)-mediated signaling is one of the hallmarks of all eukaryotes. Prokaryotic homologs of Ub (ThiS and MoaD) and E1 ligases have been studied in relation to sulfur incorporation reactions in thiamine and molybdenum/tungsten cofactor biosynthesis. However, there is no evidence...

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Autori principali: Iyer, Lakshminarayan M, Burroughs, A Maxwell, Aravind, L
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1779556/
https://ncbi.nlm.nih.gov/pubmed/16859499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2006-7-7-r60
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