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Cochlear Pharmacokinetics with Local Inner Ear Drug Delivery Using a Three-Dimensional Finite-Element Computer Model

HYPOTHESIS: Cochlear fluid pharmacokinetics can be better represented by three-dimensional (3D) finite-element simulations of drug dispersal. BACKGROUND: Local drug deliveries to the round window membrane are increasingly being used to treat inner ear disorders. Crucial to the development of safe th...

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Detalhes bibliográficos
Main Authors: Plontke, Stefan K., Siedow, Norbert, Wegener, Raimund, Zenner, Hans-Peter, Salt, Alec N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1779502/
https://ncbi.nlm.nih.gov/pubmed/17119332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000097246
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