Human, viral or mutant human IL-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis

IL-10 is a Th2 cytokine important for inhibiting cell-mediated immunity while promoting humoral responses. Human IL-10 (hIL-10) has anti-inflammatory, immunosuppressive as well as immunostimulatory characteristics, whereas viral IL-10 (vIL-10), a homologue of hIL-10 encoded by Epstein Barr virus (EB...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Keravala, Annahita, Lechman, Eric R, Nash, Joan, Mi, Zhibao, Robbins, Paul D
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2006
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1779418/
https://ncbi.nlm.nih.gov/pubmed/16704745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1960
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