Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases

Background: We have recently shown that the severity of human colonic familial adenomatous polyposis (FAP) varies in a manner consistent with the action of modifier genes. These modifier genes may harbour common alleles which increase the risk of colorectal cancer (CRC) in the general population. An...

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Hlavní autoři: Crabtree, M D, Fletcher, C, Churchman, M, Hodgson, S V, Neale, K, Phillips, R K S, Tomlinson, I P M
Médium: Artigo
Jazyk:Inglês
Vydáno: Copyright 2004 by Gut 2004
Témata:
Colon Cancer
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1774929/
https://ncbi.nlm.nih.gov/pubmed/14724163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2003.015586
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