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Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice or intestinal tumorigenesis in Apc(Min/+) mice
Background and aims: Leptin, the product of the ob gene, has been suggested to increase the risk of colon cancer. However, we have shown that although leptin stimulates epithelial cell proliferation it reduces the development of carcinogen induced preneoplastic lesions in the rat colon. Here, we exp...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
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Copyright 2005 by Gut
2005
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1774895/ https://ncbi.nlm.nih.gov/pubmed/15857934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2004.060533 |
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