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Specific interaction of tissue-type plasminogen activator (t-PA) with annexin II on the membrane of pancreatic cancer cells activates plasminogen and promotes invasion in vitro

Background: Overexpression of tissue plasminogen activator (t-PA) in pancreatic cancer cells promotes invasion and proliferation in vitro and tumour growth and angiogenesis in vivo. Aims: To understand the mechanisms by which t-PA favours cancer progression, we analysed the surface membrane proteins...

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Autors principals: Díaz, V M, Hurtado, M, Thomson, T M, Reventós, J, Paciucci, R
Format: Artigo
Idioma:Inglês
Publicat: Copyright 2004 by Gut 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1774091/
https://ncbi.nlm.nih.gov/pubmed/15194650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2003.026831
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