Glucocorticoid receptors are downregulated in hepatic T lymphocytes in rats with experimental cholangitis

Background and aims: Primary sclerosing cholangitis is a Th1 cytokine driven disease with a poor clinical responsiveness to glucocorticoid therapy. We have previously documented elevated circulating glucocorticoid levels in cholestatic rats and in addition have noted increased hepatic expression of...

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Autores principales: Tjandra, K, Le, T, Swain, M G
Formato: Artigo
Lenguaje:Inglês
Publicado: Copyright 2003 by Gut 2003
Materias:
Liver
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1773774/
https://ncbi.nlm.nih.gov/pubmed/12912871
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