Defining the roles of perforin, Fas/FasL, and tumour necrosis factor α in T cell induced mucosal damage in the mouse intestine

Background and aims: Mucosal flattening and epithelial cell apoptosis are typical features of T cell induced inflammatory diseases of the bowel, such as coeliac disease and graft versus host disease. Mice injected with a T cell activating anti-CD3 antibody develop a severe diarrhoeal illness. We des...

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Main Authors: Merger, M, Viney, J L, Borojevic, R, Steele-Norwood, D, Zhou, P, Clark, D A, Riddell, R, Maric, R, Podack, E R, Croitoru, K
Formato: Artigo
Idioma:Inglês
Publicado: Copyright 2002 by Gut 2002
Assuntos:
Inflammation and Inflammatory Bowel Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1773316/
https://ncbi.nlm.nih.gov/pubmed/12117872
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