Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator

The yeast GCN5 (yGCN5) transcriptional coactivator functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Here, we present the high resolution crystal structure of the HAT domain of yGCN5 and probe the functional importance of a conserved glutamate residue. The structu...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Trievel, Raymond C., Rojas, Jeannie R., Sterner, David E., Venkataramani, Ravichandran N., Wang, Lian, Zhou, Jianxin, Allis, C. David, Berger, Shelley L., Marmorstein, Ronen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17710/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10430873/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.16.8931
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