Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator

The yeast GCN5 (yGCN5) transcriptional coactivator functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Here, we present the high resolution crystal structure of the HAT domain of yGCN5 and probe the functional importance of a conserved glutamate residue. The structu...

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Detalhes bibliográficos
Main Authors: Trievel, Raymond C., Rojas, Jeannie R., Sterner, David E., Venkataramani, Ravichandran N., Wang, Lian, Zhou, Jianxin, Allis, C. David, Berger, Shelley L., Marmorstein, Ronen
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC17710/
https://ncbi.nlm.nih.gov/pubmed/10430873
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