Cell cycle regulation by the Wee1 Inhibitor PD0166285, Pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line

BACKGROUND: Wee1 kinase plays a critical role in maintaining G2 arrest through its inhibitory phosphorylation of cdc2. In previous reports, a pyridopyrimidine molecule PD0166285 was identified to inhibit Wee1 activity at nanomolar concentrations. This G2 checkpoint abrogation by PD0166285 was demons...

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Main Authors: Hashimoto, Osamu, Shinkawa, Masako, Torimura, Takuji, Nakamura, Toru, Selvendiran, Karuppaiyah, Sakamoto, Masaharu, Koga, Hironori, Ueno, Takato, Sata, Michio
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2006
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1770931/
https://ncbi.nlm.nih.gov/pubmed/17177986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-6-292
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