Potent urea and carbamate inhibitors of soluble epoxide hydrolases
The soluble epoxide hydrolase (sEH) plays a significant role in the biosynthesis of inflammation mediators as well as xenobiotic transformations. Herein, we report the discovery of substituted ureas and carbamates as potent inhibitors of sEH. Some of these selective, competitive tight-binding inhibi...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17696/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10430859/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.16.8849 |
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