All-trans retinoic acid induces COX-2 and prostaglandin E(2 )synthesis in SH-SY5Y human neuroblastoma cells: involvement of retinoic acid receptors and extracellular-regulated kinase 1/2

BACKGROUND: Our recent results show that all-trans retinoic acid (ATRA), an active metabolite of vitamin A, induces COX-dependent hyperalgesia and allodynia in rats. This effect was mediated by retinoic acid receptors (RARs) and was associated with increased COX-2 expression in the spinal cord. Sinc...

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Hlavní autoři: Alique, Matilde, Herrero, Juan F, Lucio-Cazana, Francisco Javier
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2007
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1769480/
https://ncbi.nlm.nih.gov/pubmed/17204142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-4-1
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