Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis

Familial amyotrophic lateral sclerosis-linked mutations in copper-zinc superoxide dismutase cause motor neuron death through one or more acquired toxic properties. An early event in the mechanism of toxicity from such mutants is now demonstrated to be activation of caspase-1. Neuronal death, however...

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Main Authors: Pasinelli, Piera, Houseweart, Megan K., Brown, Robert H., Cleveland, Don W.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2000
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC17673/
https://ncbi.nlm.nih.gov/pubmed/11095709
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