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Mechanism-based discovery of ligands that counteract inhibition of the nicotinic acetylcholine receptor by cocaine and MK-801

Nicotinic acetylcholine receptors (AChR) belong to a family of proteins that form ligand-gated transmembrane ion channels. They are involved in the fast transmission of signals between cells and the control of intercellular communication in the nervous system. A variety of therapeutic agents and abu...

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Autori principali: Hess, George P., Ulrich, Henning, Breitinger, Hans-Georg, Niu, Li, Gameiro, Armanda M., Grewer, Christof, Srivastava, Sanjay, Ippolito, Joseph E., Lee, Sean M., Jayaraman, Vasanthi, Coombs, Susan E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC17672/
https://ncbi.nlm.nih.gov/pubmed/11095713
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