AN MHC CLASS II DISPARITY RAISES THE THRESHOLD FOR TOLERANCE INDUCTION IN PULMONARY ALLOGRAFTS IN MINIATURE SWINE

OBJECTIVES: The mechanisms and treatment of chronic rejection in pulmonary allotransplantation remain elusive. We have induced robust tolerance to class I-disparate lung allografts in miniature swine using an intensive 12-day course of tacrolimus. Here, we test whether a tolerant state can be induce...

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Main Authors: Shoji, Tsuyoshi, Sahara, Hisashi, Muniappan, Ashok, Guenther, Dax A., Houser, Stuart L., Pujara, Akshat C., Bravard, Marjory A., Wain, John C., Sachs, David H., Madsen, Joren C., Allan, James S.
Format: Artigo
Language:Inglês
Published: 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1766937/
https://ncbi.nlm.nih.gov/pubmed/17175245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.transproceed.2006.10.161
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