A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: Implications for filovirus budding

VP40, the putative matrix protein of both Ebola and Marburg viruses, possesses a conserved proline-rich motif (PY motif) at its N terminus. We demonstrate that the VP40 protein can mediate its own release from mammalian cells, and that the PY motif is important for this self-exocytosis (budding) fun...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Harty, Ronald N., Brown, Melissa E., Wang, Guangli, Huibregtse, Jon, Hayes, Felicia P.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17668/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11095724/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.250277297
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