A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: Implications for filovirus budding

VP40, the putative matrix protein of both Ebola and Marburg viruses, possesses a conserved proline-rich motif (PY motif) at its N terminus. We demonstrate that the VP40 protein can mediate its own release from mammalian cells, and that the PY motif is important for this self-exocytosis (budding) fun...

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Bibliografiske detaljer
Main Authors: Harty, Ronald N., Brown, Melissa E., Wang, Guangli, Huibregtse, Jon, Hayes, Felicia P.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC17668/
https://ncbi.nlm.nih.gov/pubmed/11095724
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