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D1–D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of G(q)/11 in the striatum
We demonstrate a heteromeric D1–D2 dopamine receptor signaling complex in brain that is coupled to G(q)/11 and requires agonist binding to both receptors for G protein activation and intracellular calcium release. The D1 agonist SKF83959 was identified as a specific agonist for the heteromer that ac...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1766439/ https://ncbi.nlm.nih.gov/pubmed/17194762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604049104 |
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