D1–D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of G(q)/11 in the striatum

We demonstrate a heteromeric D1–D2 dopamine receptor signaling complex in brain that is coupled to G(q)/11 and requires agonist binding to both receptors for G protein activation and intracellular calcium release. The D1 agonist SKF83959 was identified as a specific agonist for the heteromer that ac...

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Bibliographische Detailangaben
Hauptverfasser: Rashid, Asim J., So, Christopher H., Kong, Michael M. C., Furtak, Teresa, El-Ghundi, Mufida, Cheng, Regina, O'Dowd, Brian F., George, Susan R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1766439/
https://ncbi.nlm.nih.gov/pubmed/17194762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604049104
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