A 19F nuclear magnetic resonance study of uptake and metabolism of 5-fluorocytosine in susceptible and resistant strains of Candida albicans.

The metabolism of the antifungal drug 5-fluorocytosine (5-FC) was studied in intact viable cells of Candida albicans by 19F nuclear magnetic resonance (NMR). The uptake of the drug and its conversion to the deaminated product 5-fluorouracil (5-FU) were easily observed by NMR analysis of both the cel...

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Hauptverfasser: Di Vito, M, Podo, F, Torosantucci, A, Carpinelli, G, Whelan, W L, Kerridge, D, Cassone, A
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1986
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC176396/
https://ncbi.nlm.nih.gov/pubmed/3521476
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