A 19F nuclear magnetic resonance study of uptake and metabolism of 5-fluorocytosine in susceptible and resistant strains of Candida albicans.

The metabolism of the antifungal drug 5-fluorocytosine (5-FC) was studied in intact viable cells of Candida albicans by 19F nuclear magnetic resonance (NMR). The uptake of the drug and its conversion to the deaminated product 5-fluorouracil (5-FU) were easily observed by NMR analysis of both the cel...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Di Vito, M, Podo, F, Torosantucci, A, Carpinelli, G, Whelan, W L, Kerridge, D, Cassone, A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1986
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC176396/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3521476/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.29.2.303
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