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Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids

The bacteriophage P1 Cre/loxP system has become a powerful tool for in vivo manipulation of the genomes of transgenic mice. Although in vitro studies have shown that Cre can catalyze recombination between cryptic “pseudo-loxP” sites in mammalian genomes, to date there have been no reports of loxP-si...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Schmidt, Edward E., Taylor, Deborah S., Prigge, Justin R., Barnett, Sheila, Capecchi, Mario R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The National Academy of Sciences 2000
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC17639/
https://ncbi.nlm.nih.gov/pubmed/11087830
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