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Hydrodynamic Delivery of Cre Protein to Lineage-Mark or Time-Stamp Mouse Hepatocytes In situ

Cre-responsive fluorescent marker alleles are powerful tools for cell lineage tracing in mice; however their utility is limited by regulation of Cre activity. When targeting hepatocytes, hydrodynamic delivery of a Cre-expression plasmid can convert Cre-responsive alleles without inducing the intrace...

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Autors principals: Sonsteng, Katherine M., Prigge, Justin R., Talago, Emily A., June, Ronald K., Schmidt, Edward E.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953374/
https://ncbi.nlm.nih.gov/pubmed/24626158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091219
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